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This changed in 2016 when the Federal Drug Administration (FDA) released a statement urging doctors to use caution when prescribing this medication to pregnant patients. Diflucan is different from other treatments for vaginal yeast infections because it is a tablet taken by mouth Diflucan is the brand name for a drug called fluconazole. This medication is commonly used for vaginal yeast infections but also can be used for deep fungal infections. ** Please Note: Prices, promotions, styles and availability may vary by store and online. When taken orally, this magic little pill stays in your system for roughly 72 hours and goes to work by attacking the cell walls of the Candida fungi that are causing your infection. If your symptoms don’t improve in 2 days, you should take the second dose of 150 mg fluconazole. About 11% of the dose is excreted in the urine as metabolites. When the cell walls are damaged, the fungus dies and “presto”– your yeast. 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